Table of Contents

Historical milestones and discoveries that shaped the toxicology sciences.- Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment.- The role of biotransformation and bioactivation in toxicity.- Genotoxicity: damage to DNA and its consequences.- Role of DNA repair in the protection against genotoxic stress.- On the impact of the molecule structure in chemical carcinogenesis.- Chemical induced alterations in p53 signaling.- Molecular pathways involved in cell death after chemically induced DNA damage.- The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways.- Mapping the epigenome — impact for toxicology.- Receptors mediating toxicity and their involvement in endocrine disruption.- Toxicogenomics: transcription profiling for toxicology assessment.- The role of toxicoproteomics in assessing organ specific toxicity.- High-throughput screening for analysis of in vitro toxicity.