Table of Contents

Prologue (in praise of cells); 1. The first look at a genome (sequence statistics); 2. All the sequence's men (gene finding); 3. All in the family (sequence alignment); 4. The boulevard of broken genes (hidden Markov models); 5. Are Neanderthals among us? (variation within and between species); 6. Fighting HIV (natural selection at the molecular level); 7. SARS: a post-genomic epidemic (phylogenetic analysis); 8. Welcome to the hotel Chlamydia (whole genome comparisons); 9. The genomics of wine-making (analysis of gene expression); 10. A bed-time story (identification of regulatory sequences); Appendix.

Promotional Information

Self-contained and entertaining introduction to computational genomics, using a case-studies approach with Matlab demos.

About the Author

Nello Cristianini is a Professor of Artificial Intelligence, University of Bristol Matthew Hahn is an Assistant Professor at the Department of Biology and School of Informatics, Indiana University