Table of Contents

The IGF-I Gene: Structure, Expression, and Gene Products. The Insulin-Like Growth Factor I Receptor: Molecular Biology, Heterogeneity and Regulation. Biological Actions of the Insulin-Like Growth Factors. Insulin-Like Growth Factor II: Gene Structure and Expression into Messenger RNA and Protein. The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor. Insulin-Like Growth Factor Binding Proteins. Insulin. Structure and Function of the Insulin Receptor. Is Insulin a Growth Factor? Regulation of Insulin, IGF-I and IGF-II Gene Expression.Molecular (genetic) aspects of growth factorsBinding proteins and receptorsFactors affecting gene transcription and translation