Introduction
General Mechanistic Considerations
Nucleophilic Substitution at Aliphatic Carbon
Nucleophilic Addition to Electron-deficient C=C Double Bonds
Nucleophilic Addition to C=N Double Bonds
Nucleophilic Addition to C=O Double Bonds
Nucleophilic Addition to Unsaturated Nitrogen
Cycloaddition Reactions
Protonation of Enolates and Tautomerization of Enols
Oxidation
Reduction of Carbonyl Compounds
Kinetic Resolution of Racemic Alcohols and Amines
Desymmetrization and Kinetic Resolution of Anhydrides
Large-Scale Applications
Appendix: Tabular Survey of Organo-Catalysts, Synthesis and
Application
Albrecht Berkessel is full professor at the university of Cologne,
Germany. His research interests are catalysis, combinatorial
chemistry and solid phase chemistry.
Harald Groger is currently working at the Degussa AG. His research
is focussed on enzymatic reactions and biocatalysis.
"This fascinating monograph captures the diversity and power of an
area of research whose roots extend deep within the organic
chemistry literature, yet which has only recently achieved critical
mass through the collective contributions of many present-day
pioneers. ... is an essential addition to both academic and
industrial research libraries, as well as to the personal
collection of any scientist with an interest in catalysis or
synthetic chemistry." Angewandte Chemie I.E.
"... well-written with clear, focused schemes... of great value to
those involved in synthetic methodology, catalysis, and total
synthesis." Journal of the American Chemical Society
"On the whole, the authors succeeded in covering a very broad range
of reactions that are catalyzed by organic catalysts, and offer
readers an excellent overview of the current situation in the field
of asymmetric organocatalysis. This book can be recommended for all
scientists working in the area of asymmetric catalysis, whether in
industrial research and development or at the universities.
Postgraduate students and postdoctoral researchers who have begun
work on this rapidly growing field would derive considerable
benefit from reading it."
Synthesis
"This monograph will be a valuable addition into personal
collections of synthetic chemists and research libraries of
academia and industry." E-STREAMS
"Bas Buch von Berkessel und Gröger ist eine umfangreiche
Monographie über die asymmetrische Organokatalyse. Obwohl es
schwierig ist, ein Buch über ein sich so rasch entwickelndes Gebiet
zu schreiben, ist es den Autoren gelungen, dieses auf aktuellen
Stand zu bringen. ... Die Lektüre dieses Buches sollte Pflicht sein
für alle, die sich mit Organokatalyse befassen. Darüber hinaus ist
es all denjenigen zu empfehlen, die sich für asymmetrische Katalyse
oder organische Synthese interessieren. Das Buch gehört in jede
chemische Bibliothek, und sollte in die Lehre der modernen Methoden
der organischen Chemie Eingang finden."
Maria Hechavarria Fonseca, Mülheim/Ruhr, Nachrichten aus der
Chemie, 05/2005
"...wird Generationen von Chemikern als Einführung in die moderne
asymmetrische Organokatalyse dienen: Es ist das Buch schlechthin
zum Thema."
Christian Burstein, Frank Glorius, Philipps-Universität Marburg
Angewandte Chemie + International Edition 2005 - 117/28
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