Table of Contents

I: Regulation by Reversible Protein Phosphorylation.- Control of Cellular Processes by Reversible Protein Phosphorylation.- From Phosphorylase to Phosphorylase Kinase.- Protein Kinase X: A Novel Human Protein Kinase Closely Related to the Catalytic Subunit of cAMP-Dependent Protein Kinase.- Interaction of Protein Kinase Ac from Ascaris Suum with Proteins and Peptides: Comparison with the Mammalian Enzyme.- II: Methodology.- Interaction Studies Using Biosensors.- Advances in Determination of Protein Structure by X-ray Diffraction Methods.- Spectroscopical Studies on the Interaction Between WW Domain and Proline-Rich Peptides.- Novel Microscope-Based Approaches for the Investigation of Protein-Protein Interactions in Signal Transduction.- Binding Studies with SH2 Domains from the Phosphotyrosine Kinase ZAP70 Using Surface Plasmon Resonance and Scintillation Proximity Assays.- Leucine Zipper Mediated Homodimerization of Autoantigen L7 Analyzed by Electrospray Ionization Mass Spectrometry and Yeast Two Hybrid Interactions.- Proteins at Work: Time-Resolved FTIR Studies of Bacteriorhodopsin and the GTP-Binding Protein 21.- III: Phospholipid Signaling.- Downstream Signaling from Phosphoinositide 3-Kinase.- Phosphoinositide-3-Kinase Mediated Activation of JNK by the ßPDGFR.- Regulation of Phospholipase C Isozymes.- Substrate Binding and Catalytic Mechanism in Phospholipase C from Bacillus Cereus.- Identification of Three Active Site Residues Involved in Substrate Binding by Human 43 kDa-D-myo-inositol 1,4,5-trisphosphate 5-phosphatase.- Structural Basis of Protein Ligand Interactions in the Pleckstrin Homology Domain.- IV: Tyrosine Phosphorylation and Downstream Signaling.- Cell Signaling by Tyrosine Phosphorylation: The Other Side of the Coin.- Binding Studies on the NeuronalIsoform of the Non-Receptor Protein Tyrosine Kinase pp60c-src, pp60c-srcN and Potential Target Proteins.- The Switch Cycle of the Ras Protein and Its Role in Signal Transduction.- In Vivo Quantitative Assessment of Ras/Raf Interaction Using the Two-Hybrid System.- In Vivo Analysis of c-Raf1 — 14-3-3 Interaction.- Signal Transduction Through the MAP Kinase Pathway.- Identification and Characterization of MKKX, a Novel Mammalian MAP Kinase Kinase.- Interleukin-1 Activates a Novel p54 MAP Kinase Kinase in Rabbit Liver.- The Protein Kinase B Family — Structure, Regulation and Function.- Regulation of p70s6k.- Rapamycin, FRAP and the Control of 5’TOP mRNA Translation.- Structure, Regulation and Targeting of Protein Phosphatase 2A.- The Constitutive Activation of MET, RON and SEA Genes Induces Different Biological Responses.- Nucleoside Diphosphate Kinase: Effect of the P100S Mutation on Activity and Quaternary Structure.- V: Regulatory Cascades.- Interaction of Adenylyl Cyclase Type 1 with ?? Subunits of Heterotrimeric G-Proteins.- Regulation of G-Protein Activation in Retinal Rods by Phosducin.- Selective Interactions of the Rat ?-Opioid Receptor and a Chimeric ?-Opioid Receptor Expressed in COS-7 Cells with Multiple G Proteins.- Structural Requirements for the EF-Tu-Directed Kinase.- Effect of the Phytotoxin Fusicoccin on Plant Plasma Membrane H+-ATPase Expressed in Yeast.- Organization and Putative Regulation of the Glucose-Specific Phosphotransferase System from Staphylococcus Carnosus.- VI: Regulation of Muscle Contraction.- Single Molecule Myosin Mechanics Measured Using Optical Trapping.- Studies on the ATP-Binding Site of Actin Using Site-Directed Mutagenesis.- Characterisation of the Actin-Binding Protein Insertin.- Cardiac Troponin.- Studies on theFunction of the Different Phosphoforms, of Cardiac Troponin I.

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